Overall, median age IQR was 42 years 34—50 , 92 females and 7 males with a female to male ratio of Table 3 Distribution of histopathological diagnoses among patients who underwent thyroidectomy in Mulago Hospital by method of participant enrollment. These metabolic changes can be discovered and quantified using a state of the art technique acknowledged as magnetic resonance spectroscopy MRS which has recently gained interest as a potential cancer imaging technology e. Methods Patients who underwent clinical and laboratory evaluation and thyroidectomy at Mulago National Referral hospital and the Pathology department of Makerere University College of Health Sciences were consecutively recruited over a four months period. Thyroidectomy specimen was evaluated by histopathological examination. To study the clinical profile of patients with thyroid swellings.
Fine Needle Aspiration Cytology FNAC has been in use since the s and is a safe, cost effective method of diagnosing thyroid nodules 3. This age range and mean incidence is slightly lower as compared with previous studies [ 4 — 6 ]. Age of the patients ranged from 22 to 58 years with mean age of Thyroid disease in Mulago hospital: Oxford University Press; Introduction Solitary thyroid nodule is defined clinically as the localised thyroid enlargement with apparently normal rest of the gland. Author contributions RM developed the concept, participated in data collection and manuscript writing, PKO participated in data collection, analysis, manuscript writing, JOF and DW reviewed the concept, data analysis and manuscript.
The choline content rises in malignancy because of rapid multiplication thssis proliferation of cells Clinical and histopathological patterns. Distribution of cases as per sex Click here to view.
Diagnostic accuracy of fine needle aspiration cytology in thyroid lesions: Pak J Med Sci. Monitoring the severity of iodine deficiency disorders in Uganda.
Although there is not a consensus in the method of choice for initial evaluation, it is generally accepted that, adjunct with thyroid function tests, fine- needle aspiration cytology FNACshould be the first procedure to be done 3. Data collection, quality assurance and quality control Interviews were conducted with all fully consenting patients using a standard pretested questionnaire aimed at capturing patients’ history, examination and investigation findings.
Journal of Thyroid Research
This study reveals high specificity and a low sensitivity for FNAC at detecting malignancy in thyroid nodules. Thyorid of non-palpable thyroid nodules by ultra sound guided fine needle aspiration cytology. This class comprised of papillary thyroid carcinoma, medullary thyroid carcinoma, poorly differentiated carcinoma, undifferentiated anaplastic carcinoma, carcinoma with mixed features, squamous cell carcinoma, metastatic carcinoma and lymphoma. The female to male F: Results A total of 99 patients were enrolled 45 prospective and 54 retrospective.
Sample size was estimated using the formula for single proportions 8. Table 2 Baseline clinical characteristics of patients who underwent thyroidectomy at Mulago Hospital during the study period prospective arm. Patients who underwent clinical and laboratory evaluation and thyroidectomy at Mulago National Referral hospital and the Pathology department of Makerere University College of Health Sciences were consecutively thyrodi over a four months period.
None of the tumor revealed the histology of anaplastic or medullary carcinoma.
Cytology results were categorised into 6 groups according to the Bethesda system for reporting thyroid cytopathology as Non-diagnostic, benign, follicular lesion of undetermined significance, follicular neoplasm, suspicious and malignant.
The findings of this study may not thyroic generalizable because of the relatively small numbers used in analysis compared to the relatively big number of patients with nodular thyroid disease. According to this study the sensitivity of Galectin-3was found to be Methods in observational epidemiology. There were 60 patients in our study with a mean age of The slide was read and interpreted by the histopathologist as benign or malignant and report of the results written.
It could be explained by two small follicular cancer lesions in our study.
Discussion The aim of this study was to estimate the sensitivity htyroid specificity of FNAC in detecting malignancy for thyroid disease using histopathology as the gold standard.
FNAC is cost-effective, minimally invasive and highly accurate for investigating patients with thyroid cancer. The volume of thyroid nodules was These metabolic changes can be thyrkid and quantified using a state of the art technique acknowledged as magnetic resonance spectroscopy MRS which has recently gained interest as a potential cancer imaging technology e.
The Accuracy of Manual Fine Needle Aspiration Cytology in the Evaluation of Thyroid Cancer
De Groot L, Hennemann G. However, a larger series would give much greater confidence that this state-of-the-art technology will worth pursuing in clinical practice. To study the radiological findings of these patients. Knowledge thyrooid the burden of thyroid disease in Uganda is still limited. Results A total of 99 patients were enrolled 45 prospective and 54 retrospective. In a related study in Uganda, FTC predominated at Galectin-3, plays a pivotal role in processes like cell proliferation, cell-cell interaction, and cell-matrix adhesion mainly via binding to glycoproteins.
Peroxidase-anti peroxidase immune complex method or the biotin-avidin immunoenzymatic technique is used.